Figure 6
From: A novel approach to identify driver genes involved in androgen-independent prostate cancer
Shuttle vector mutagenesis models a major mechanism whereby DSB-induced rearrangements dysregulate genes. In panel A two loci are shown where a strong promoter expresses gene X and a weaker regulated promoter expresses gene Y. In panel B a DSB-induced rearrangement places gene Y under the control of the gene X promoter, dysregulating gene Y and thereby promoting PCa progression. In panel C an integrated shuttle vector provirus enhances expression of gene Y promoting PCa progression.