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Figure 5 | Molecular Cancer

Figure 5

From: Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells

Figure 5

Analysis of PI3K/AKT signaling. A: Sequencing results for PIK3CA A3140G corresponding to the H1047R mutation in the catalytic subunit of PI3 kinase are shown as histograms. B: Phospho-protein and total protein levels for AKT were examined by Western Blotting. C-D: No differential response between wild-type and BRAF-mutant cell clones was found in proliferation assays. E: In Western blot analysis, PI-103 inhibited phosphorylation of AKT residues T-308 and S-473 in a dose-dependent manner in all cell clones.

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Molecular Cancer

ISSN: 1476-4598