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Figure 2 | Molecular Cancer

Figure 2

From: microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

Figure 2

miR-139-5p inhibited colon cancer cell growth in vitro and in vivo . (A) Ectopic expression of miR-139-5p in colon cancer cell lines DLD1 and HCT116 were evidence by qRT-PCR after transfection of pre-miR-139. (B) miR-139-5p significantly inhibited DLD1 and HCT116 cell viability. Cell growth rates were detected by MTS assay. (C) miR-139-5p inhibited DLD1 and HCT116 cells colony formation (left panel). Quantitative analysis of DLD1 and HCT116 colony numbers (n = 3, mean ± SD) (right panel). (D) miR-139-5p inhibited colon cancer cell growth in vivo. Tumor growth curve of pre-miR-139-5p and control transfected HCT116 cells in nude mice. Data are mean ± SD (n = 4/group) (left panel). Images of the tumors induced by pre-miR-139-5p or control were shown (right panel).

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