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Figure 4 | Molecular Cancer

Figure 4

From: microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

Figure 4

miR-139-5p inhibited colon cancer cell migration and invasion. (A) Re-expression of miR-139-5p in DLD1 and SW1116 cells significantly inhibited cell migration ability as determined by cell migration assay (left panel) Quantitative analysis of migrated cell in DLD1 and SW1116. The data are means ± SD. (B) The inhibition on cell migration by miR-139-5p was further confirmed by wound-healing assay. (C) Re-expression of miR-139-5p in DLD1 and SW1116 cells significantly suppressed cell invasive ability as determined by cell invasion assay. (D) miR-139-5p significantly downregulated MMP7 and MMP9 protein levels in both colon cancer cell lines.

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