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Figure 4 | Molecular Cancer

Figure 4

From: DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells

Figure 4

DTX3L- and ARTD9-mediated proliferation, chemo-resistance and survival in PC3 cells is dependent on STAT1. (A-C) Cell proliferation analyses of PC3-siMock, PC3-siSTAT1, PC3-siSTAT1/siDTX3L (A), PC3-siSTAT1/siARTD8 (B), or PC3-siSTAT1/siARTD9 (C), double knockdown cells in presence or absence of IFNγ (200 U/ml) were assessed by the trypan blue exclusion assay. Relative cell proliferation and cell numbers are presented as mean from three independent experiments performed in triplicate, the error bars represent the SE. Statistical analysis was performed using the Student's t test. *P < 0.05, **P < 0.001 and ***P < 0.0001. (D) Cell viability analyses of a PC3-siMock, PC3-siSTAT1 single knockdown, and PC3-siSTAT1/siDTX3L PC3-siSTAT1/siARTD8 or PC3-siSTAT1/siARTD9 double knockdown cells were assessed by the trypan blue exclusion assay. Cells were treated as indicated with IFNγ and/or docetaxel (DT), NT: not treated, CT: control treatment (solvent). Values represent the means of three independent experiments performed in triplicates, and the error bars represent the SE. Statistical analysis was performed using the Student's t test. *P < 0.05, **P < 0.001 and ***P < 0.0001.

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Molecular Cancer

ISSN: 1476-4598