Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

Table 1 Cell line characteristics and the status of ACVR1B and SMAD4

Cell lines	Source	Histology	ACVR1B		SMAD4
			CN	Expression	CN	Expression
Sui65	Peritoneum	Tubular	0	-	0	-
Sui66	Pancreas	Tubular	1	+	2	++
Sui67	Pancreas	Tubular	1	-	1	+
Sui68	Pancreas	Ad	0	-	1	+
Sui70	Pancreas	Ad	2	+	0	-
Sui71	Liver	Ad	1	+	0	-
Sui73	Pancreas	Tubular	2	+	2	+
Sui74	Pancreas	Tubular	1	+	1	-

ACVR1B, activin receptor A, type IB; Tubular, tubular adenocarcinoma; Ad, adenocarcinoma; CN, gene copy number.
Legend: The copy numbers of the ACVR1B gene in the Sui65 and Sui68 cell line was 0, and the copy numbers of the SMAD4 gene in the Sui65, Sui70, and Sui71 cell lines were all 0. ACVR1B mRNA was scarcely expressed in the Sui65 and Sui68 cell lines, and SMAD4 mRNA was also scarcely expressed in the Sui65, Sui70, and Sui71 cell lines. These results were similar to those for the copy number assay.

ISSN: 1476-4598