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Table 1 Multivariate analysis of prognostic factors in PDAC patients (n = 108)

From: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

Variable

Forward stepwisea

Backward stepwiseb

 

HRc(95% CId)

p

HR (95% CI)

p

Location of tumor

 

0.074

 

0.004*

Head

-

 

1

 

Body and tail

-

 

2.178 (1.274-3.725)

 

Differentiation

 

0.022*

 

0.007*

Well

1

 

1

 

Moderate

1.560 (0.681-3.572)

0.293

1.726 (0.752-3.961)

0.198

Poor

3.775 (1.302-10.943)

0.014*

4.807 (1.661-13.913)

0.004*

TNM staging

 

0.089

 

0.015*

IA + IB

-

 

1

 

IIA

-

0.804

2.694 (1.163-6.240)

0.021*

IIB

-

0.666

2.892 (1.306-6.404)

0.009*

III + IV

-

0.039

4.277 (1.746-10.476)

0.001*

Serum CA19-9 (kU/L)

 

0.036*

 

0.028*

≤ 39

1

 

1

 

> 39

1.803 (1.038-3.130)

 

1.881 (1.071-3.304)

 

YY1

 

0.004*

 

0.032*

Low level overexpression

1

 

1

 

High level overexpression

0.416 (0.229-0.756)

 

0.511 (0.277-0.944)

 
  1. aForward stepwise, the parameters entered one by one, each time the parameter with the smallest p-value was entered, until the parameters not entered have no significance; bBackward stepwise, all parameters entered the first-time, and then removed one by one, each time removing the parameter with the largest p-value, until all of the parameters retained have significance; cHR, hazard ratio; d95% CI, 95% confidence interval; *p < 0.05.