|
Variable
|
Forward stepwisea
|
Backward stepwiseb
|
|---|
| |
HRc(95% CId)
|
p
|
HR (95% CI)
|
p
|
|---|
|
Location of tumor
| |
0.074
| |
0.004*
|
|
Head
|
-
| |
1
| |
|
Body and tail
|
-
| |
2.178 (1.274-3.725)
| |
|
Differentiation
| |
0.022*
| |
0.007*
|
|
Well
|
1
| |
1
| |
|
Moderate
|
1.560 (0.681-3.572)
|
0.293
|
1.726 (0.752-3.961)
|
0.198
|
|
Poor
|
3.775 (1.302-10.943)
|
0.014*
|
4.807 (1.661-13.913)
|
0.004*
|
|
TNM staging
| |
0.089
| |
0.015*
|
|
IA + IB
|
-
| |
1
| |
|
IIA
|
-
|
0.804
|
2.694 (1.163-6.240)
|
0.021*
|
|
IIB
|
-
|
0.666
|
2.892 (1.306-6.404)
|
0.009*
|
|
III + IV
|
-
|
0.039
|
4.277 (1.746-10.476)
|
0.001*
|
|
Serum CA19-9 (kU/L)
| |
0.036*
| |
0.028*
|
|
≤ 39
|
1
| |
1
| |
|
> 39
|
1.803 (1.038-3.130)
| |
1.881 (1.071-3.304)
| |
|
YY1
| |
0.004*
| |
0.032*
|
|
Low level overexpression
|
1
| |
1
| |
|
High level overexpression
|
0.416 (0.229-0.756)
| |
0.511 (0.277-0.944)
| |
- aForward stepwise, the parameters entered one by one, each time the parameter with the smallest p-value was entered, until the parameters not entered have no significance; bBackward stepwise, all parameters entered the first-time, and then removed one by one, each time removing the parameter with the largest p-value, until all of the parameters retained have significance; cHR, hazard ratio; d95% CI, 95% confidence interval; *p < 0.05.
