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Table 1 Multivariate analysis of prognostic factors in PDAC patients (n = 108)

From: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

Variable Forward stepwisea Backward stepwiseb
  HRc(95% CId) p HR (95% CI) p
Location of tumor   0.074   0.004*
Head -   1  
Body and tail -   2.178 (1.274-3.725)  
Differentiation   0.022*   0.007*
Well 1   1  
Moderate 1.560 (0.681-3.572) 0.293 1.726 (0.752-3.961) 0.198
Poor 3.775 (1.302-10.943) 0.014* 4.807 (1.661-13.913) 0.004*
TNM staging   0.089   0.015*
IA + IB -   1  
IIA - 0.804 2.694 (1.163-6.240) 0.021*
IIB - 0.666 2.892 (1.306-6.404) 0.009*
III + IV - 0.039 4.277 (1.746-10.476) 0.001*
Serum CA19-9 (kU/L)   0.036*   0.028*
≤ 39 1   1  
> 39 1.803 (1.038-3.130)   1.881 (1.071-3.304)  
YY1   0.004*   0.032*
Low level overexpression 1   1  
High level overexpression 0.416 (0.229-0.756)   0.511 (0.277-0.944)  
  1. aForward stepwise, the parameters entered one by one, each time the parameter with the smallest p-value was entered, until the parameters not entered have no significance; bBackward stepwise, all parameters entered the first-time, and then removed one by one, each time removing the parameter with the largest p-value, until all of the parameters retained have significance; cHR, hazard ratio; d95% CI, 95% confidence interval; *p < 0.05.