Figure 2
From: USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
USP18 expression in tumor cells suppresses tumor growth in vivo. 3 × 105 B16-OVA-shUSP18 or B16-OVA-shCon tumor cells were intravenously inoculated into C57BL/6 mice. Tumor growth was monitored by counting the lung tumor foci (A-B) and the survival rate (C). 2 × 105 B16-OVA-USP18 or B16-OVA-GFP tumor cells were intravenously inoculated into C57BL/6 mice. Tumor growth was monitored by counting the lung tumor foci (D-E), and mouse survival rate over time (F). 1 × 106 B16-OVA-USP18 or B16-OVA-GFP, or B16-OVA-shUSP18 tumor cells were subcutaneously inoculated into C57BL/6 mice. The tumor growth was monitored as tumor volume and by H&E staining (G-I).