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Figure 5 | Molecular Cancer

Figure 5

From: Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

Figure 5

Nutlin-3 potentiates the anti-tumor effects of arsenic trioxide in vivo . (A) Representative bioluminescence images corresponding to the SMMC7721/As orthotopic hepatic tumors formed in the liver of the nude mice. (B) Volume of SMMC7721/As orthotopic tumors was determined at different time points. Data points represent the mean ± SD. (***P < 0.001, two-way ANOVA with Bonferroni post-test). (C) Representative images of sections stained with anti-Ki-67 antibody, or with anti-cleaved caspase-3 antibody. (D) Cells expressing Ki-67 were counted to calculate the proliferation index; cleaved caspase-3-positive cells were counted to give the apoptosis index. (*P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA with Bonferroni post-test). (E) The representative H&E staining of pulmonary metastasis (arrows) on 5wk (left panel) and the average number of foci per mouse were calculated (right panel); (***P < 0.001, two-way ANOVA with Bonferroni post-test).

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