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Figure 3 | Molecular Cancer

Figure 3

From: Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

Figure 3

Activation of Notch1 signaling pathway increased the sensitivity of MG63 and Saos-2 to cisplatin. Real-time PCR indicated that HES1 mRNA in MG63 and Saos-2 had significantly more expression after NICD-1 plasmid transfection (A and B). The sensitivity of MG63 and Saos-2 to cisplatin has significantly increased after the activation of Notch1 signaling pathway (C and D). (*Pā€‰<ā€‰0.05; **Pā€‰<ā€‰0.01).

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