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Figure 4 | Molecular Cancer

Figure 4

From: Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

Figure 4

Inhibition of Notch1 signaling pathway decreased the sensitivity of MG63 and Saos-2 to cisplatin. Real-time PCR indicated that HES1 mRNA in MG63 and Saos-2 had significantly less expression after DAPT treatment (A and B). The sensitivity of MG63 and Saos-2 to cisplatin has significantly decreased after the inhibition of Notch1 signaling pathway (C and D). (*P < 0.05; **P < 0.01).

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Molecular Cancer

ISSN: 1476-4598