Skip to main content


Figure 4 | Molecular Cancer

Figure 4

From: Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

Figure 4

Inhibition of Notch1 signaling pathway decreased the sensitivity of MG63 and Saos-2 to cisplatin. Real-time PCR indicated that HES1 mRNA in MG63 and Saos-2 had significantly less expression after DAPT treatment (A and B). The sensitivity of MG63 and Saos-2 to cisplatin has significantly decreased after the inhibition of Notch1 signaling pathway (C and D). (*Pā€‰<ā€‰0.05; **Pā€‰<ā€‰0.01).

Back to article page