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Figure 5 | Molecular Cancer

Figure 5

From: Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

Figure 5

Notch1 signaling pathway regulated cisplatin sensitivity of MG63 and Saos-2 via changing the apoptosis effect. After overexpression of NICD-1, cisplatin could induce more apoptosis in MG63 and Saos2 cells than their control group (A and B). When Notch1 signaling pathway was inhibited by DAPT, cisplatin induced fewer apoptosis cells in both osteosarcoma cell lines (C and D). (*Pā€‰<ā€‰0.05; **Pā€‰<ā€‰0.01).

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