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Figure 1 | Molecular Cancer

Figure 1

From: β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro

Figure 1

β-Alanine alters glycolytic and oxidative metabolism in breast epithelial cells. (A) Basal glycolytic metabolism reported as extracellular acidification rate (ECAR) following treatment of either MCF-7 or MCF-10a cells with β-Alanine, D-Alanine, or L-Valine at 100 mM for 24 hours. (B) Peak glycolytic metabolism (induced with oligomycin) for cells following treatment as described above. (C) Proton production rate during basal metabolism. (D) Basal oxidative metabolism reported as oxygen consumption rate (OCR) following treatment as described above. (E) Oxidative reliance expressed as a ratio of OCR:ECAR. (F) Cellular ATP production of both cell models following treatment as described above. NOTES: *indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001 compared with control. v indicates P < 0.05 compared with L-Valine control. a indicates P < 0.05 compared with D-Alanine control.

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Molecular Cancer

ISSN: 1476-4598