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Figure 3 | Molecular Cancer

Figure 3

From: β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro

Figure 3

β-Alanine selectively suppresses mitochondrial content and related gene expression in malignant breast epithelial cells. (A) PGC-1α mRNA induction measured by qRT-PCR of MCF-7 and MCF-10a cells treated with and without β-Alanine for 24 hours. (B) PGC-1α protein expression following treatment as described above (representative blots displayed in D). (C) Mitochondrial content measured by flow cytometry following Mitotracker green staining of MCF-7 and MCF-10a cells treated with and without β-Alanine for 24 hours. (D) Representative immunoblots of MCF-7 cells (left) and MCF-10a cells (right). NOTES: *indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001 compared with control.

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Molecular Cancer

ISSN: 1476-4598