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Figure 1 | Molecular Cancer

Figure 1

From: Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab

Figure 1

Identification of a somatic EGFR mutation in colorectal adenocarcinoma via whole genome sequencing. (A) Depiction of the somatic structural rearrangements in this colorectal cancer genome by a Circos plot. The chromosomes are depicted along the circle with somatic rearrangements depicted in purple (interchromosomal) and green (intrachromosomal), including a deletion at the APC tumor suppressor locus. (B) Depiction of numbers of candidate mutations and non-synonymous alterations in coding genes, and mutations in known cancer genes, TP53 and EGFR. (C) Schematic of somatic EGFR mutations found in glioblastoma (green lettering), lung adenocarcinoma (blue lettering) and colorectal adenocarcinoma (red lettering), with insertions and deletions above the domain structure, and substitution mutations below the domain structure indicated by red dots.

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