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Table 2 Proportional hazards Cox regression models evaluating the association between miR-10b RERs and Overall Survival (OS), Disease Free Survival (DFS) and Metastases Free Survival (MFS) in the 90 cases without metastases at diagnosis

From: Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients

Outcome Median follow-up (range)* Events/Total Model HR 95% CI p
Disease Free Survival (DFS) 39.88 (21.17 – 58.77) 34/90 Univariable 1.16 1.02-1.31 0.021
31/79 Multivariable 1.30 1.11-1.51 <0.001
Metastasis-Free Survival (MFS) 43.57 (25.23 – 59.77) 30/90 Univariable 1.17 1.03-1.34 0.019
27/79 Multivariable 1.34 1.13-1.59 <0.001
Overall Survival (OS) 45.78 (32.60 – 60.50) 18/90 Univariable 1.20 1.04-1.38 0.015
   16/79 Multivariable 1.31 1.10-1.57 0.003
  1. Abbreviations: HR Hazard Ratio, 95% CI, 95% Confidence Interval.
  2. Multivariable models included: T, N, Grade, ER, PgR, HER2 and KI67.
  3. HR were reported for each unitary increase of 0.1 miR-10b RERs.