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Figure 1 | Molecular Cancer

Figure 1

From: Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

Figure 1

Inhibition of Chk1 inhibits cell proliferation in human leukemia and lymphoma cell lines. (A) Kinase selectivity profile of V158411. V158411 was screened at 50 nM, duplicate single-point against a panel of 386 wild-type kinases using DiscoveRx KINOME scanMAX technology. (B) V158411 inhibited the proliferation of leukemia and lymphoma cell lines compared to colon and lung cancer cell lines following 72 hour exposure to the drug. Values are the average of at least 4 determinations. (C) Comparison of V158411 and PF-477736 anti-proliferative activity against leukaemia and lymphoma cell lines compared to colon and lung cancer cell lines following 72 hour exposure to the drug. Values are the average of at least 4 determinations ± SD. (D) Regression analysis of V158411 and PF-477736 GI50 values. GI50 values from Figure 1C were converted to pGI50 values and plotted. R2 value was calculated using a linear trendline in Excel.

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Molecular Cancer

ISSN: 1476-4598