Cell cycle changes induced in leukemia and lymphoma cells by V158411. (A) Cell cycle profiles of Jurkat, Raji and U937 cells were determined by PI staining following treatment with the indicated concentrations of V158411 for 24 or 48 hours. (B) Quantification of the cell cycle changes observed after 24 hour treatment to V158411. (C) Comparison of the fraction of cells in G2 and M relative to G1 in cells treated with DMSO or the concentration of V158411 approximately equivalent to the GI50 for 24 hours. (D) V158411 treatment for 24 hours increased the percentage of leukemia and lymphoma cells with a sub-G1 DNA content.