Skip to main content
Figure 5 | Molecular Cancer

Figure 5

From: Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

Figure 5

Chk1 inhibition by V158411 induces Chk1 degradation and H2AX phosphorylation. (A) Cells were treated with the indicated concentrations of V158411 for 24 hours. (B) Jurkat and Raji cells were treated with 1 μM V158411 for the indicated times. (C) Jurkat and Raji cells were treated with 1 μM V158411 in the presence or absence of 10 μM MG132 for 24 hours. Protein expression was characterized by western blotting with GAPDH used as a loading control.

Back to article page