Skip to main content

Table 1 Growth inhibition of leukemia and lymphoma cell lines by V158411 and PF-477736

From: Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

Cell line p53 status GI50(μM) ± SD Tumor type
   V158411 PF-477736  
HL60 Mut 0.21 ± 0.083 0.73 ± 0.033 Promyelocytic Leukemia
Jurkat Mut 0.12 ± 0.07 0.12 ± 0.046 T-cell Lymphoma
K562 Mut 2.8 ± 1.6 1.9 ± 1.4 Chronic Myelogenous Leukemia
MV4-11 WT 0.063 ± 0.033 0.13 ± 0.051 Acute Monocytic Leukemia
Raji Mut 0.42 ± 0.14 0.33 ± 0.11 Burkett’s Lymphoma
U937 Mut 0.034 ± 0.018 0.099 ± 0.006 Histiocytic Lymphoma
  1. Mut, mutant; WT, wild type. GI50 values are the mean of n ≥ 4 ± SD.