Table 1 Growth inhibition of leukemia and lymphoma cell lines by V158411 and PF-477736
Cell line | p53 status | GI50(μM) ± SD | Tumor type | |
|---|---|---|---|---|
V158411 | PF-477736 | |||
HL60 | Mut | 0.21 ± 0.083 | 0.73 ± 0.033 | Promyelocytic Leukemia |
Jurkat | Mut | 0.12 ± 0.07 | 0.12 ± 0.046 | T-cell Lymphoma |
K562 | Mut | 2.8 ± 1.6 | 1.9 ± 1.4 | Chronic Myelogenous Leukemia |
MV4-11 | WT | 0.063 ± 0.033 | 0.13 ± 0.051 | Acute Monocytic Leukemia |
Raji | Mut | 0.42 ± 0.14 | 0.33 ± 0.11 | Burkett’s Lymphoma |
U937 | Mut | 0.034 ± 0.018 | 0.099 ± 0.006 | Histiocytic Lymphoma |