Overlap between the PSNE gene signature and gene sets of cancer and premalignant related models. (A) Ingenuity Pathway Analysis of the proportion of genes of the PSNE signature belonging to the Diseases and disorders category with a p value <0.0001. (B) Ingenuity Pathway Analysis of the percentage of genes of the cancer category in A involved in common cancer types. (C) List of the genes from the PSNE signature overlapping with data sets of pre-malignant non-melanoma skin pathologies from [14–19]. Were considered as overlapping only the genes differentially regulated in the same direction in each set.