Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

Table 1 Functional categorization of genes from the PSNE signature

*Category*	*Term*	P-*value*	*Count up*	% up	*Count down*	% *down*	*group*
GO molecular function
GO:0008081	Phosphoric diester hydrolase activity	0.00207	5	1.74	2	0.69	1
GO:0051082	Unfolded protein binding	0.00225	5	1.74	3	1.04	2
GO:0016491	Oxidoreductase activity	0.00292	21	7.34	1	0.34	3
GO:0008483	Transaminase activity	0.0041	0	0	4	1.39	4
GO:0015175	Neutral amino acid transmembrane transporter activity	0.0042	0	0	4	1.39	5
GO biological process
GO:0042180	Cellular ketone metabolic process	2.02E-8	11	3.78	20	6.87	6
GO:0009605	Response to external stimulus	1.16E-6	24	8.24	13	4.46	7
GO:0008544	Epidermis development	2.44E-6	12	4.12	3	1.03	8
GO:0006950	Response to stress	6.51E-6	31	10.65	22	7.56	9
GO:0042221	Response to chemical stimulus	1.47E-5	28	9.62	15	5.15	10

The top five Gene Ontology terms within the “Molecular function” and the “Biological process” subcategories and associated p-values are listed. The number and percentage of up- and down-regulated genes in each subcategory are indicated. A group number was attributed to each subcategory in order to spot the genes belonging to each subcategory in Additional file 2: Table S1.

ISSN: 1476-4598