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Table 1 Functional categorization of genes from the PSNE signature

From: Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

Category Term P-value Count up % up Count down % down group
GO molecular function
GO:0008081 Phosphoric diester hydrolase activity 0.00207 5 1.74 2 0.69 1
GO:0051082 Unfolded protein binding 0.00225 5 1.74 3 1.04 2
GO:0016491 Oxidoreductase activity 0.00292 21 7.34 1 0.34 3
GO:0008483 Transaminase activity 0.0041 0 0 4 1.39 4
GO:0015175 Neutral amino acid transmembrane transporter activity 0.0042 0 0 4 1.39 5
GO biological process
GO:0042180 Cellular ketone metabolic process 2.02E-8 11 3.78 20 6.87 6
GO:0009605 Response to external stimulus 1.16E-6 24 8.24 13 4.46 7
GO:0008544 Epidermis development 2.44E-6 12 4.12 3 1.03 8
GO:0006950 Response to stress 6.51E-6 31 10.65 22 7.56 9
GO:0042221 Response to chemical stimulus 1.47E-5 28 9.62 15 5.15 10
  1. The top five Gene Ontology terms within the “Molecular function” and the “Biological process” subcategories and associated p-values are listed. The number and percentage of up- and down-regulated genes in each subcategory are indicated. A group number was attributed to each subcategory in order to spot the genes belonging to each subcategory in Additional file 2: Table S1.