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Table 2 KEGG functional annotation of genes from the PSNE signature

From: Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

KEGG pathway

P-value

Genes

Hsa00980 : Metabolism of xenobiotics by cytochrome P450

0.0011

AKR1C3, AKR1C2, GSTA4, ADH5, GSTP1, MGST2, ALDH3A1

Hsa00970 : Aminoacyl-tRNA biosynthesis

0.0087

IARS, WARS, AARS, GARS, MARS

Hsa00260 : Glycine, serine and threonine metabolism

0.0234

CTH, SHMT2, PSAT1, CBS

Hsa00010 : Glycolysis/Gluconeogenesis

0.0315

LDHA, ADH5, BPGM, PCK2, ALDH3A1

Hsa05020 : Prion diseases

0.0322

IL1B, HSPA5, PRNP, IL1A

  1. The top five over-represented molecular pathways of the PSNE signature using KEGG pathway analysis.