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Table 3 IPA annotation of genes from the PSNE signature

From: Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

Ingenuity canonical pathways P-value Genes
Metabolism of xenobiotics by cytochrome P450 0.000126 ADH5, AKR1C2, AKR1C3, MGST2, GSTA4, CYP4B1, ALDH3A1, GSTP1
Glycine, Serine and Threonine Metabolism 0.00138 PSAT1, CBS, GARS, CTH, PLCH2, PLCL1, SHMT2
Interferon signaling 0.000257 IFIT1, OAS1, MX1, IFNGR1, PSMB8
Aminoacyl-tRNA biosynthesis 0.000295 WARS, GARS, AARS, MARS, IARS
Aldosterone signaling in epithelial cells 0.001175 HSPA8, CRYAB, DNAJB4, HSPA9, PLCH2, DNAJA1, HSPA5, PLCL1, HSPB1
  1. The top five over-represented molecular pathways of the PSNE signature using Ingenuity Pathway Analysis.