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Table 3 IPA annotation of genes from the PSNE signature

From: Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

Ingenuity canonical pathways

P-value

Genes

Metabolism of xenobiotics by cytochrome P450

0.000126

ADH5, AKR1C2, AKR1C3, MGST2, GSTA4, CYP4B1, ALDH3A1, GSTP1

Glycine, Serine and Threonine Metabolism

0.00138

PSAT1, CBS, GARS, CTH, PLCH2, PLCL1, SHMT2

Interferon signaling

0.000257

IFIT1, OAS1, MX1, IFNGR1, PSMB8

Aminoacyl-tRNA biosynthesis

0.000295

WARS, GARS, AARS, MARS, IARS

Aldosterone signaling in epithelial cells

0.001175

HSPA8, CRYAB, DNAJB4, HSPA9, PLCH2, DNAJA1, HSPA5, PLCL1, HSPB1

  1. The top five over-represented molecular pathways of the PSNE signature using Ingenuity Pathway Analysis.