Figure 5
Clinical survival analysis according to the levels of TSDR-DMR in different tissue samples. Essentially, patients with lower DMRs, both in tumor samples (Figure 5A, 5D) and normal samples (Figure 5B, 5E), tended to have better survival when compared to patients with higher DMRs. However, the difference was significant only for RFS according to the variable DMRN (Figure 5E, p = 0.022). And no significant difference was found either for OS (Figure 5C) or for RFS (Figure 5F) according to the variables of relative TSDR demethylation level (DMRT/DMRN). DMRs were classified as high or low in relation to the median values for each (see Additional file 1: Tables S1 and Additional file 2: Table S2). Log-rank (Mantel-Cox) tests were performed for the overall comparisons. Reference lines within the graphs indicate the 5th year and 3rd year for OS and RFS, respectively.