Table 2 Cox analysis of the prognostic variables on the overall and recurrence-free survival in patients

Univariate analysis

Gender, Male/Female

0.342

1.357 (0.723-2.550)

0.301

0.602 (0.230-1.576)

Age, ≤60/>60 years

0.494

0.802 (.425-1.510)

0.607

0.787 (.315-1.963)

Maximum Size, ≤5/>5 cm

0.321

1.394 (0.724-2.683)

0.700

1.207 (0.463-3.149)

Location, Left side/Right side

0.129

1.649 (0.864-3.145)

0.365

1.557 (0.597-4.062)

Differentiation, G1-G2/G3-G4

0.038*

1.959 (1.039-3.694)

0.807

0.891 (0.354-2.245)

Mucinous or signet-ring carcinoma, No/Yes

0.684

0.851 (0.391-1.851)

0.354

0.557 (0.162-1.918)

CEA, Normal/Elevated

0.054

1.874 (0.990-3.547)

0.015*

4.144 (1.311-13.099)

Tumor (T) stage, T1-2/T3-4

0.061

0.256 (0.062-1.064)

0.920

0.927 (.210- 4.085)

Nodal (N) status, N0/N1-2

0.504

0.807 (0.430-1.514)

0.121

2.140 (.818- 5.598)

Distant metastases (M), M0/M1^a

0.000*

8.412 (4.332-16.338)

AJCC Stage, I-II/ III-IV

0.002*

3.155 (1.533-6.490)

0.551

0.762 (.312-1.860)

Lymphatic/vascular invasion, No/Yes

0.268

1.440 (0.755-2.746)

0.455

0.691 (0.263-1.821)

Perineural invasion, No/Yes

0.354

1.444 (0.664-3.142)

0.085

0.168 (0.022-1.275)

Extranodal tumor deposit, No/Yes

0.000*

4.341 (2.216-8.504)

0.236

2.126 (0.611-7.399)

DMR_T level, Low/High

0.493

1.246 (0.664-2.339)

0.070

2.320 (0.934-5.761)

DMR_N level, Low/High

0.153

1.588 (0.843-2.994)

0.030*

2.709 (1.102-6.662)

DMR_T/DMR_N, Low/High

0.884

1.048 (0.558-1.967)

0.876

0.926 (0.353-2.431)

Multivariate analysis

Distant metastases (M), M0/M1

0.000*

7.431 (3.864-14.291)

Differentiation, G1-G2/G3-G4

0.518

1.250 (0.635-2.459)

AJCC Stage, I-II/III-IV

0.885

1.074 (0.406-2.846)

Extranodal tumor deposit, No/Yes

0.330

1.479 (0.673-3.248)

CEA, Normal/Elevated

0.015*

4.144 (1.311-13.099)

DMR_N level, Low/High

0.286

1.733 (0.631-4.755)