Figure 3
From: Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells
Light activated DTIC blocks melanoma cell proliferation. A and B, DNA content FACS analysis of D10 and MM485 cell lines treated with TMZ or DTIC for 72 hr. C, Proliferation assay. WM266-4 cells were treated with DTIC or the MEK inhibitor selumetinib and EdU incorporation was measured 24, 48 or 72 hours after drug addition as indicated; untreated cells were set 100%. One-way Anova was used to compare the effect of each treatment with untreated cells. *p < 0.05, **p < 0.01, ***p < 0.001.