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Table 1 Testis weight, sperm concentration and length of seminiferous tubule in bortezomib treated and control mice

From: Bortezomib treatment causes long-term testicular dysfunction in young male mice

Follow-up period

Group

Testis weight, both sides (mg) n=6

Sperm concentration (106/ml) n = 6

Length of seminiferous tubules (m) n = 4

2 days

Control

91±0.001

3.30 ± 0.543

2.57 ± 0.131

Bortezomib

83 ± 0.002***

0.89 ± 0.239*

2.36 ± 0.235

45 days

Control

120 ± 0.003

4.62 ± 1.031

2.78 ± 0.103

Bortezomib

85 ± 0.003***

1.31 ± 0.148***

2.09 ± 0.123*

6 months

Control

114 ± 0.003

11.73 ± 2.027

3.01 ± 0.021

Bortezomib

80 ± 0.006***

3.12 ± 0.951***

2.40 ± 0.272

  1. Mean ± S.E.M; *P < 0.05, ***P < 0.001.