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Table 1 Testis weight, sperm concentration and length of seminiferous tubule in bortezomib treated and control mice

From: Bortezomib treatment causes long-term testicular dysfunction in young male mice

Follow-up period Group Testis weight, both sides (mg) n=6 Sperm concentration (106/ml) n = 6 Length of seminiferous tubules (m) n = 4
2 days Control 91±0.001 3.30 ± 0.543 2.57 ± 0.131
Bortezomib 83 ± 0.002*** 0.89 ± 0.239* 2.36 ± 0.235
45 days Control 120 ± 0.003 4.62 ± 1.031 2.78 ± 0.103
Bortezomib 85 ± 0.003*** 1.31 ± 0.148*** 2.09 ± 0.123*
6 months Control 114 ± 0.003 11.73 ± 2.027 3.01 ± 0.021
Bortezomib 80 ± 0.006*** 3.12 ± 0.951*** 2.40 ± 0.272
  1. Mean ± S.E.M; *P < 0.05, ***P < 0.001.