From: Bortezomib treatment causes long-term testicular dysfunction in young male mice
Follow-up period | Group | Testis weight, both sides (mg) n=6 | Sperm concentration (106/ml) n = 6 | Length of seminiferous tubules (m) n = 4 |
---|---|---|---|---|
2 days | Control | 91±0.001 | 3.30 ± 0.543 | 2.57 ± 0.131 |
Bortezomib | 83 ± 0.002*** | 0.89 ± 0.239* | 2.36 ± 0.235 | |
45 days | Control | 120 ± 0.003 | 4.62 ± 1.031 | 2.78 ± 0.103 |
Bortezomib | 85 ± 0.003*** | 1.31 ± 0.148*** | 2.09 ± 0.123* | |
6 months | Control | 114 ± 0.003 | 11.73 ± 2.027 | 3.01 ± 0.021 |
Bortezomib | 80 ± 0.006*** | 3.12 ± 0.951*** | 2.40 ± 0.272 |