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Figure 6 | Molecular Cancer

Figure 6

From: Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer

Figure 6

Identification of miR-130a as a target of HOTAIR. (A) pcDNA3.1-HOTAIR upregulated the HOTAIR mRNA level. (B, C) Downregulation of miR-130a by ectopic expression of HOTAIR detected by RT-PCR (B) and northern blot (C). GBC-SD cells were transfected with vector control or HOTAIR or mutant HOTAIR, and total RNA was isolated 48 h after transfection. (D) The mutant HOTAIR at putative binding site. Error bars represent S.E.M., n = 3. *p < 0.05; **p < 0.01.

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