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Figure 4 | Molecular Cancer

Figure 4

From: Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2

Figure 4

Sorafenib does not block metronomic CPA-stimulated recruitment of innate immune cells to 9L tumors. (A, B, C) qPCR analysis of mouse (host) TSP1, NK1.1 and perforin 1 in 9L tumors treated with vehicle, sorafenib alone, or metronomic CPA ± sorafenib as in Figure 3A and isolated 6 days after the 2nd, 4th, and 6th CPA cycles (i.e., treatment days 12, 24, and 36), as indicated. Bars, mean ± SE for n = 5-6 tumors/group. Horizontal dashed line: expression level in untreated (UT) group on day 12. (D) Representative immunostained images of NK cell marker NK1.1, with hematoxylin counterstaining, in tumors collected on treatment day 24.

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Molecular Cancer

ISSN: 1476-4598