IC50s
|
VEGFR1 (nM)
|
VEGFR2 (nM)
|
VEGFR3 (nM)
|
PDGFR (nM)
|
c-kit (nM)
|
Refs
|
---|
Axitinib
|
0.1
|
0.06-0.1 (0.25)
|
0.1-0.3
|
3-30
|
1-2
|
[31]
|
AG-028262
|
~0.1
|
<1 (0.34)
|
~0.1-0.3
|
193
| |
[39, 40]
|
Cediranib (AZD2171)
|
5
|
<1 (~0.5)
|
<1-3
|
5
|
2
|
[32]
|
Sorafenib
|
~26
|
15-90
|
~10-30
|
~10-30
|
68
|
[30, 33]
|
- Shown are IC50 values reported in the indicated references for inhibition of each human receptor protein. IC50 values for inhibition of mouse VEGFR2 are shown in parenthesis.