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Figure 5 | Molecular Cancer

Figure 5

From: Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

Figure 5

R clones remain sensitive to anti-CD20 monoclonal antibody rituximab. 51Cr release assay was used to assess the impact of the anti-CD20 monoclonal antibody rituximab on complement mediated cytotoxicity (CMC) and antibody dependent cellular cytotoxicity (ADCC). CMC was measurable only in HBL-2 cells (both CTRL and R), but was negligible in the remaining four MCL cell populations (both CTRL and R). In HBL-2 R clone the CMC was significantly increased compared to CTRL. ADCC was measurable in all five MCL cell lines. In JEKO-1 R clone the ADCC was slightly decreased compared to CTRL. In GRANTA-519 R clone the ADCC was significantly increased compared to CTRL. In MINO, REC-1 and HBL-2 the ADCC remained comparable between R clone and CTRL cells.

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Molecular Cancer

ISSN: 1476-4598