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Figure 9 | Molecular Cancer

Figure 9

From: Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling

Figure 9

Schematic representation of the pathway of TH-mediated cell motility. Schematic representation of the pathway of TH-mediated cell motility. Addition of T3 (10 nM) to HepG2-TR α cells activates BSSP4 expression via direct binding of TR proteins to TRE (-609 ~ -594) of the BSSP4 promoter. P-ERK and C/EBPβ were upregulated in the nucleus, and VEGF was highly secreted in the medium of the BSSP4-overexpressed and T3-treated hepatoma cells. EMT-related proteins, such as E-cadherin and N-cadherin, were also influenced by BSSP4. BSSP4 and T3 exerted similar effects to promote cell motility via the EMT process and ERK-C/EBP β-VEGF cascade in hepatoma cells.

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