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Figure 6 | Molecular Cancer

Figure 6

From: Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer

Figure 6

Tamoxifen-resistant breast cancer cells expressing LSR are sensitive to iota toxin. (A) Tamoxifen-resistant breast cancer cell lines were grown to 80% confluence, and lysates analyzed via western blot using LSR- and CD44-specific antibodies; α-tubulin was used as a loading control. (B) Cells were treated with Ia or Ia + Ib for 8 h and representative images demonstrate cell rounding and detachment from tissue culture dish, indicative of cell death. (C) Cell death was quantitated at the indicated times via fluorescent cytotoxicity assay. *P < 0.05. A minimum of three independent experiments was performed for each analysis. RFU; relative fluorescent units.

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Molecular Cancer

ISSN: 1476-4598