Molecular Cancer

Table 1 Iota toxin sensitivity in a breast cancer cell line panel

From: Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer

	Cell line	Ia (10 ng/ml)	Ia (10 ng/ml) + Ib (20 ng/ml)	Ia (25 ng/ml) + Ib (50 ng/ml)	Ia (50 ng/ml) + Ib (100 ng/ml)	Ia (100 ng/ml) + Ib (200 ng/ml)
Luminal	MCF-7	-	+	+	++	++
	T47D	-	+	+	+	++
	ZR-75-1	-	+	+	++	++
Basal-like	HCC1937	-	++	++	++	++
	MDA-MB-468	-	+	+	++	++
	SUM149	-	-	-	+	++
	BT-20	-	-	+	+	+
	SUM190	-	-	+	+	+
	HCC1143	-	++	++	++	++
Claudin-low	SUM1315mo	-	+	+	+	+
	SUM159	-	-	-	-	-
	MDA-MB-231	-	-	-	+	+
	Hs578T	-	-	-	-	-
	BT-549	-	-	-	-	-

(−) Resistant, 0 to 10% cell rounding; (+) Sensitive, 11 to 50% cell rounding; (++) Highly Sensitive, >50% cell rounding. Toxin Sensitivity recorded at 8 h post treatment.

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ISSN: 1476-4598

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