Figure 2

Overexpression of miR-200c suppress NSCLC cells metastases in vivo. (A and B) Representative gross photo of a mouse lung and the images of histological inspection of a mouse lung for the presence of microscopic lesions twelve weeks after tail vein injection (xenograft) with SPC-A-1 cells stably expressing the miR-200c inhibitor or miR-control inhibitor lentiviral vector, and eight weeks after tail vein injection (xenograft), twelve weeks after subcutaneous injection (subcutaneous) with SPC-A-1sci cells stably expressing the miR-200c or miR-control lentiviral vector. (C) Quantification of lung microscopic nodules in the lungs of each group. Statistical analysis was performed using Student’s t- test. Error bars represent S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001.