Claudin-1 overexpression promotes inflammation driven colon tumorigenesis. (A) Endoscopic images were obtained from APCMin and APC-Cldn1 mice under conditions of regular drinking water (control) (n = 3) and 2% DSS w/v in drinking water (treated) (n = 5) mice at the indicated time points, following 7 days of DSS administration. (B) Tumor number/mice in DSS-treated APCMin versus APC-Cldn1 mice (p = 0.022) (C) Representative H&E images. Values are mean ± S.E.M. *p < 0.05.