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Table 1 Comparative histological analysis of colon tumors

From: Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

Genotype No. mice with tumors Average no. tumors per mouse* Total no. mice w/ HGD** Total no. invasive adenocarcinomas Total no. of adenomas
APC (n = 18) 15 1.28 2 0 22
APC-Cldn1 (n = 16) 16 2.76 11 1 45
  1. Abbreviation: HGD high grade dysplasia.
  2. *p = 0.003.
  3. **Logistic regression for likelihood of developing HGD p = 0.0007.
  4. Colon tumors were quantitated from APCMin and APC-Cldn1 mice and were classified as high grade dysplasia (HGD), adenomas and invasive adenocarcinomas.