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Table 1 Comparative histological analysis of colon tumors

From: Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

Genotype

No. mice with tumors

Average no. tumors per mouse*

Total no. mice w/ HGD**

Total no. invasive adenocarcinomas

Total no. of adenomas

APC (n = 18)

15

1.28

2

0

22

APC-Cldn1 (n = 16)

16

2.76

11

1

45

  1. Abbreviation: HGD high grade dysplasia.
  2. *p = 0.003.
  3. **Logistic regression for likelihood of developing HGD p = 0.0007.
  4. Colon tumors were quantitated from APCMin and APC-Cldn1 mice and were classified as high grade dysplasia (HGD), adenomas and invasive adenocarcinomas.
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Molecular Cancer

ISSN: 1476-4598