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Table 4 Summary of previous studies on BRAF mutation in colorectal carcinoma

From: A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma

Study Country % with BRAF BRAF mutation detected Methods of mutation detection
Li-Ling H, 2012 Taiwan 1.1 2/182 High-resolution melting point (HRM) polymerase chain reaction (PCR) for BRAF V600E mutations
Li H , 2011 China 7 14/200 Sequenced by Pyrosequencer PyroMark ID system-Exon 15, V600E
Liou J, 2011 China 3.8 12/314 Sequencing of exons 11 and 15
Yokota T, 2011 Japan 4.7 15/319 Cycleave PCR technique for V600E mutation
Nakanishi R, 2012 Japan 6.7 17/254 BRAF pyrokit pyrosequencing
Ajay Goel, 2009 Israel 18.7 24/128 Direct sequencing using the BigDye version 1.1 cycle-sequencing kit
Rozek L, 2010 Israel 5 65/1300 Direct sequencing of exon 15 of BRAF
Price T, 2011 Australia 10.6 33/315 High-resolution melting point (HRM) polymerase chain reaction (PCR) for BRAF V600E mutations
Tran B, 2011 Australia 11 57/524 Mutation-specific real-time polymerase chain reaction assay.
Di Nicolantonio, 2008 Italy 10 11/113 Automated sequencing by ABI PRISM 3730 exon15
Richman S, 2009 UK 7.9 422/711 Pyrosequenced on a PyroMark ID system (Biotage AB) Codon 600
Roth A, 2009 Switzerland 7.9 103/1307 Allelic discrimination assay on a 7500 real-time polymerase chain reaction for V600E
Zlobec I, 2010 Switzerland 12 45/374 BRAF (exon 15 codon 600) direct sequencing of single-stranded PCR products using the BigDyeVR Terminator v1.1 cycle sequencing kit
Farina-Sarasqueta A, 2010 Netherlands 19.8 59/297 V600E mutation on the BRAF gene by real-time PCRLight Cycler v2.0 (Roche)
Saridaki Z, 2010 Greece 8.3 12/144 Real-time PCR using the allelic discrimination method with ABI PRISM 7900 T Sequence Detection System
Modest D, 2012 Germany 11.6 17/146 Exons 11 and 15 of the BRAF pyro-sequencing
Samowitz W, 2005 USA 9.5 87/911 Sequencing in both directions
Shaukat A,2010 USA 21.8 36/165 BRAF V600E mutation -Mutector II BRAF/Ras mutation detection panel assay kit
Kalady M,2012 USA 12 56/475 Direct sequencing
Ogino S,2012 USA 15 11/75 c.1799 T > A (p.V600E) mutation