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Figure 3 | Molecular Cancer

Figure 3

From: Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells

Figure 3

MiR-126 targets CXCL12 and VCAM1. a: Schematic representation of matching sequence between CXCL12 3’UTR mRNA and miR-126. b: Luciferase activity of HUVECs transfected with reporter plasmid (CXCL12-pEZX), treated with LAMA84 exosomes and/or contrasfected with miR-126 inhibitor or miR-126 mimic. c: Schematic representation of matching sequence between VCAM1 3’UTR mRNA and miR-126. d: Luciferase activity of HUVECs transfected with reporter plasmid (VCAM1-pEZX), treated with LAMA84 exosomes and/or contrasfected with miR-126 inhibitor or miR-126 mimic. For normalization, Renilla luciferase activity was used. Values are the mean ± SD of 3 independent experiments *p 0.05; **p 0.01.

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Molecular Cancer

ISSN: 1476-4598