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Figure 2 | Molecular Cancer

Figure 2

From: Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin

Figure 2

Ponatinib inhibits the growth of neoplastic cells expressing PDGFRα. (A) Ponatinib inhibited the cell viability of FIP1LI-PDGFRα-expressing cells. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to increasing concentrations of ponatinib, sorafenib or imatinib for 72 h, and cell viability was evaluated by MTS assay. Graphs show data from 3 independent experiments; error bars represent 95% confidence intervals. (B) Clonogenicity of BaF3-WT or -T674I FIP1L1-PDGFRα cells was inhibited by ponatinib in a concentration-dependent manner. Error bars represent 95% confidence intervals. (C) Effect of ponatinib on cell cycle distribution in CEL cells. CEL cells were exposed to ponatinib for 24 h. Cells were fixed and analyzed by FACScalibur after staining with propidium iodide. Histograms are from representative experiments.

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Molecular Cancer

ISSN: 1476-4598