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Figure 3 | Molecular Cancer

Figure 3

From: Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner

Figure 3

Depletion of STMN3 and GSPT1 by siRNA transfection in NSCLC cells significantly reduces nicotine and EGF induced cell proliferation and invasion. (A & B) showing reduced cell proliferation of A549 cells in response to nicotine and EGF, when STMN3 and GSPT1 are depleted, (C & D) Similar results were obtained in H1650 cells. The results are representative of three independent experiments done in duplicates. (E & F) Depletion of STMN3 and GSPT1 inhibits the invasion of A549 cells upon stimulation with nicotine and EGF as compared to serum starved cells, (G & H) similar inhibition was observed in the H1650 cells. The above data are expressed as mean ± SD of three independent experiments. *represents p value <0.05 and **represents p value < 0.0005.

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Molecular Cancer

ISSN: 1476-4598