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Figure 2 | Molecular Cancer

Figure 2

From: Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling

Figure 2

Downregulation of SFRP1 renders triple negative breast cancer cells more resistant to standard chemotherapy. A) mRNA (left) and protein (right) levels of SFRP1 after siRNA mediated knockdown, as determined by qPCR and Western-Blotting, respectively. B) Chemotherapy sensitivity of MDA-MB-468 and HCC-1806 after SFRP1 knockdown was determined using MTT cell viability assay of control vs. SFRP1 knockdown cells after treatment with cytotoxic agents (significance in MDA-MB-468 for paclitaxel ***p < 0.001 for 10 pM-1 nM, for doxorubicin ***p < 0.001 for 500 pM-50 nM and for cisplatin *p < 0.05 for 50 nM-50 μM; no significant changes were found in HCC-1806), error bars = SD, n = 3.

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Molecular Cancer

ISSN: 1476-4598