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Figure 7 | Molecular Cancer

Figure 7

From: miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias

Figure 7

Effect of miR-2909 knockdown on cell cycle and apoptosis in both B-ALL and T-ALL. (A,C) Cell cycle analysis of B- (A) and T-lympoblasts (C) transfected with antagomiR-2909 (50nM) compared with control scrambled RNA-transfected lymphoblasts for 48 h. The percentage of cells in the G1 and S phases of the cell cycle was calculated with Cell Quest Pro Software. (B,D) Flow-cytometric detection of apoptosis in B- (B) and T-lymphoblasts from patients with pediatric ALL (D) relative to control scrambled RNA-transfected lymphoblasts for 48 h. Each bar represents mean ± S.D of the experiment performed in triplicate; *P < 0.05 with respect to control.

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