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Figure 4 | Molecular Cancer

Figure 4

From: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer

Figure 4

Signaling pathway of the proliferation is involved in KIF5B-RET positive cells. A & B. KIF5B-RET positively regulates the activation of the total STATs and ERK signaling pathways in positive cells. Control and enhanced KIF5B-RET expressing BEAS-2B (A) or A549 (B) cells were lysed and analyzed for phosphorylated Tyr705 STAT3 and Thr202/Tyr204 ERK1/2 by western blots. C & D. The suppression of KIF5B-RET kinase activity by ZD6474 affects both STATs and ERK signaling pathways. Positive BEAS-2B or A549 cells were treated with ZD6474 at different doses for 48 h. Cells were lysed and analyzed by western blots for indicated marker antibodies. GAPDH was used as a loading control.

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