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Figure 6 | Molecular Cancer

Figure 6

From: IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9

Figure 6

Phosphorylated p38 is overexpressed in human GA, and the expression of p-p38 positively correlates with IL-1β, MMP2, MMP9 and c-fos expression in GA tissues. A: Overexpression of p-p38 was frequently observed in GA tissues, compared to the paired non-neoplastic gastric tissues. a, P-p38 was not detected or only weakly expressed in non-neoplastic gastric tissues. b to e: different intensities of positive p-p38 expression in GA tissues. B: Expression of p-p38 positively correlated with IL-1β, MMP2, MMP9, and c-fos expression in human GA tissues. GA tissue sample exhibiting stronger IL-1β expression and stronger p-p38, MMP2, MMP9 and c-fos expression; and weaker IL-1β expression and weak p-p38, MMP2, MMP9 and c-fos expression. C: The sum scores of positive staining intensity of IHC for p-p38. ** P < 0.05 vs. paired non- neoplastic gastric tissues.

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Molecular Cancer

ISSN: 1476-4598