Skip to main content
Figure 5 | Molecular Cancer

Figure 5

From: TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas

Figure 5

Decreased proliferation potential and increased apoptotic trend due to depletion of TCAB1 resulted in smaller xenografts tumor in vivo . a. Performed IHC against proliferation markers Ki-67 and PCNA using mice xenografts section, and the sections from shTCAB1 cells displayed lower expressed Ki-67 and PCNA. b. Statistical analysis of the Ki-67 and PCNA using Aperio ImageScope software. c. Apoptotic markers Caspase 3 and Bcl-2 were performed using IHC on mice xenografts sections. In xenografts derived from shTCAB1 cells, the results showed up-regulated Caspase 3 and down-regulated Bcl-2, the statistical analysis data were not shown here. d. TUNEL assay. Analyse the apoptosis of xenografts sections using TUNEL assay. Results indicated apoptosis was significantly increased in shTCAB1 cells. Statistical analysis of the data were determined by Student’s t test (*P < 0.05, **P < 0.01, ***P < 0.005).

Back to article page