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Figure 3 | Molecular Cancer

Figure 3

From: ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex

Figure 3

ISL-1 enhances xenografted lymphoma development in vivo . (A to D) NOD-SCID (nonobese diabetic/severe combined immunodeficient) mice were injected s.c. with different NHL cells that were stably transfected with pcDNA3.1 (Control), or pcDNA3.1-ISL-1 (ISL-1) construct (A,C), pLL3.7-Non-silencer or pLL3.7-ISL1-siRNA plasmid (B,D). The tumor size was monitored at indicated days post-injection. Statistical analysis was carried out with 2-way ANOVA. (E) The mice were killed after the last measurement of tumor volume, whole-cell lysate of 2 tumor samples of each group were prepared and subjected to Western blot analysis for ISL-1 level detection. GAPDH served as an internal control.

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Molecular Cancer

ISSN: 1476-4598