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Figure 3 | Molecular Cancer

Figure 3

From: miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis

Figure 3

Effect of miR-31 expression on cell growth and migration of NPC cells. (a) By WST-1 assay, significant growth inhibition was detected in the C666-1 cell transfected with miR-31 when compared with negative control. Data shown were taken from 5 independent experiments with mean ± SEM. (b) Expression of miR-31 significantly inhibited the colony-forming ability of C666-1 cells (**p < 0.01). Representative photographs of colonies formed in each treatment were shown. Colonies formed were stained in blue by Giemsa stain. (c) Flow cytometry analysis revealed significant reduction of the percentage of cells undergoing S phase in miR-31-transfected C666-1 cells (*p < 0.05). (d) By wound healing assay, significant reduction of the migration ability of miR-31-expressing C666-1 (**P < 0.01). Representative photographs of wound healing progress of C666-1 cells transfected with negative control and miR-31 at 0 hour and 30 hours were shown.

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