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Figure 7 | Molecular Cancer

Figure 7

From: miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis

Figure 7

Knock-down of FIH1 inhibits cell proliferation and enhances p53 phosphorylation in NPC cells. (a) Expression of FIH1 was knocked down by siRNAs targeting FIH1 (siFIH1#1 and siFIH1#2). The suppression of FIH1 in C666-1 cells was confirmed by quantitative RT-PCR and Western blotting. (b) WST-1 assay demonstrated that cell proliferation was reduced in C666-1 cells treated with FIH1 siRNAs (siFIH1#1 and siFIH1#2). (c) By Western blotting, increase of phosphorylated p53 and p21 in C666-1 treated with FIH1 siRNAs was demonstrated. Knock-down of FIH1 did not induce the expression of HIFα in NPC cells.

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